| Bioactivity | Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits[1][2]. |
| Invitro | Me-IQ (Methyl-IQ; 含0.04% 或0.01% 的饮食) 导致小鼠前胃鳞状细胞癌和乳头状瘤的发生率很高。0.04% 剂量组的 Me-IQ 诱发的前胃鳞状细胞癌中约40% 转移至肝脏[1]。 |
| Name | Me-IQ |
| CAS | 77094-11-2 |
| Formula | C12H12N4 |
| Molar Mass | 212.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. H Ohgaki, et al. Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx. Princess Takamatsu Symp. 1985;16:97-105. [2]. T Aune, et al. Mutagenic activation of IQ and Me-IQ by liver and lung microsomes from rabbit and mouse, and with isolated lung cells from the rabbit. Carcinogenesis. 1986 Feb;7(2):273-6. |