| Bioactivity | Mcl-1 inhibitor 10 (compound 43) is a relatively strong MCL-1 inhibitor (IC50=0.67 μM). Mcl-1 inhibitor 10 interacts with specific binding sites of MCL-1 protein to block the pro-survival signal of MCL-1 and push cancer cells into apoptosis. Mcl-1 inhibitor 10 can be used in the study of MCL-1 dependent cancers[1]. |
| CAS | 1580484-33-8 |
| Formula | C21H15F3O4 |
| Molar Mass | 388.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Petros A M, et al. Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein[J]. Bioorganic & medicinal chemistry letters, 2014, 24(6): 1484-1488. |
Mcl-1 inhibitor 10
CAS: 1580484-33-8 F: C21H15F3O4 W: 388.34
Mcl-1 inhibitor 10 (compound 43) is a relatively strong MCL-1 inhibitor (IC50=0.67 μM). Mcl-1 inhibitor 10 interacts wi
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