| Bioactivity | Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques[1][2][3]. |
| Invitro | Maurocalcine (100 nM, 24 小时) 增加 RyR2 对激活 [Ca2+]i 的敏感性，并降低其对抑制 [Ca2+]i 的灵敏度[1]。Maurocalcine (5 μM， 4 小时/ 24 小时) 对 HEK293 完全没有细胞毒性[3]。 Cell Viability Assay[3] Cell Line: |
| Name | Maurocalcine |
| CAS | 269745-22-4 |
| Sequence | Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Leu-Cys-Lys-Glu-Asn-Lys-Asp-Cys-Cys-Ser-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys-Arg (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32) |
| Shortening | GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32) |
| Formula | C156H270N56O46S6 |
| Molar Mass | 3858.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477(20):3985-3999. [2]. Altafaj X, et al. Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification. Biochem J. 2007 Sep 1;406(2):309-15. [3]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19. |
Maurocalcine
CAS: 269745-22-4 F: C156H270N56O46S6 W: 3858.55
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine
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