Maurocalcine TFA

CAS: F: C156H270N56O46S6.xC2HF3O2 W: 3858.55 (free base)

Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocal

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Bioactivity	Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques[1][2][3].
Invitro	Maurocalcine (100 nM, 24 小时) 增加 RyR2 对激活 [Ca2+]i 的敏感性，并降低其对抑制 [Ca2+]i 的灵敏度[1]。Maurocalcine (5 μM， 4 小时/ 24 小时) 对 HEK293 完全没有细胞毒性[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Maurocalcine TFA 相关抗体: Cell Viability Assay[3] Cell Line:
Sequence	Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Leu-Cys-Lys-Glu-Asn-Lys-Asp-Cys-Cys-Ser-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys-Arg (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32)
Shortening	GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32)
Formula	C156H270N56O46S6.xC2HF3O2
Molar Mass	3858.55 (free base)
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477(20):3985-3999. [2]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19. [3]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19.