| Bioactivity | Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99=0.06 μg/mL) and inhibits motility of adult worms (EC50=2 μM). Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s=0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively. |
| CAS | 75731-43-0 |
| Formula | C28H35N3O4 |
| Molar Mass | 477.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Polonsky, et al. Isolation and structure (X-ray analysis) of marcfortine A, a new alkaloid from Penicillium roqueforti. J.C.S. Chem. Comm. 0(13), 601-602 (1980). |
Marcfortine A
CAS: 75731-43-0 F: C28H35N3O4 W: 477.60
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the para
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