| Bioactivity | Manumycin A is an antibiotic. Manumycin A acts as a selective, competitive inhibitor of protein farnesyltransferase (FTase) with respect to farnesylpyrophosphate (Ki =1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein. Manumycin A induces apoptosis and exerts antitumor activity[1] [2][3]. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling[4]. Manumycin A is a nSMase inhibitor (EC50=0.25 μM)[5]. |
| Name | Manumycin A |
| CAS | 52665-74-4 |
| Formula | C31H38N2O7 |
| Molar Mass | 550.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Manumycin A
CAS: 52665-74-4 F: C31H38N2O7 W: 550.64
Manumycin A is an antibiotic. Manumycin A acts as a selective, competitive inhibitor of protein farnesyltransferase (FTa
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