| Bioactivity | Maniwamycin E is a maniwamycin derivative isolated from the culture extract of thermotolerant Streptomyces sp. JA74. Maniwamycin E shows antiviral activity against SARS-CoV-2 and influenza (H1N1) virus[1]. |
| Invitro | Maniwamycin E (compound 2) shows inhibitory activity against the influenza (H1N1) virus infection of MDCK cells with an IC50 value of 63.2 μM, without cytotoxicity as well[1].Maniwamycin E also displays antiviral activity against SARS-CoV-2 infection of 293TA and VeroE6T cells with an IC50 value of 9.7 μM, without cytotoxicity as well[1]. |
| Name | Maniwamycin E |
| Formula | C10H20N2O2 |
| Molar Mass | 200.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shun Saito, et al. Dihydromaniwamycin E, a Heat-Shock Metabolite from Thermotolerant Streptomyces sp. JA74, Exhibiting Antiviral Activity against Influenza and SARS-CoV-2 Viruses. J. Nat. Prod. 2022, Oct 12. |