| Bioactivity | Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM[1][2]. | ||||||||||||
| Target | IC50: 0.15 μM (Malic enzyme) | ||||||||||||
| Invitro | Malic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72 hours) shows a significant reduction in total cell numbers[2]. Malic enzyme inhibitor ME1 shows a significant reduction in cell viability/metabolic activity in MTS cell[2]. Malic enzyme inhibitor ME1 dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Malic enzyme inhibitor ME1 | ||||||||||||
| CAS | 522649-59-8 | ||||||||||||
| Formula | C20H21N3O3 | ||||||||||||
| Molar Mass | 351.40 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8. [2]. Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268. |
Malic enzyme inhibitor ME1
CAS: 522649-59-8 F: C20H21N3O3 W: 351.40
Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM.
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