| Bioactivity | Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts[1]. Malantide is also an efficient substrate for PKC with a Km of 16 μM[2]. | ||||||
| Invitro | The Km values of Malantide are 15 μM and 223 μM for PKA and PKG, respectively. The Vmax values are 23.8 units/mg and 6.6 units/mg for for PKA and PKG, respectively[1].A statistically significant effect of isoprenaline on the activity ratio of guinea-pig heart was only: observed with Malantide[1]. | ||||||
| Name | Malantide | ||||||
| CAS | 86555-35-3 | ||||||
| Sequence | Arg-Thr-Lys-Arg-Ser-Gly-Ser-Val-Tyr-Glu-Pro-Leu-Lys-Ile | ||||||
| Shortening | RTKRSGSVYEPLKI | ||||||
| Formula | C72H124N22O21 | ||||||
| Molar Mass | 1633.89 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Malantide
CAS: 86555-35-3 F: C72H124N22O21 W: 1633.89
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on th
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