Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine_product_DataBase

Bioactivity	Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immune stimulator antibody conjugate (ISAC) comprising an anti-human epidermal growth factor receptor 2 (HER2) antibody, a STING agonist (ADU-S100) and a linker. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine can be uesd for cancer research (WO2018200812A1; example 5)[1].
Invitro	STING (stimulator of interferon genes) is an endoplasmic reticulum adaptor that facilitates innate immune signaling. It was reported that STING comprises four putative transmembrane regions, predominantly resides in the endoplasmic reticulum and is able to activate NF-kB, STAT6, and IRF3 transcription pathways to induce expression of type I interferon (e.g., IFN-a and IFN-β) and exert a potent anti-viral state following expression. In contrast, loss of STING rendered murine embryonic fibroblasts extremely susceptible to negative stranded virus infection, including vesicular stomatitis virus[1].
Name	Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine
CAS	2249935-19-9
Formula	C51H65N17O19P2S2.xC6H15N
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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