| Bioactivity | Mal-Pc is a versatile molecular photosensitizer designed based phthalocyanine and maleimides. Mal-Pc can react with GSH to deplete GSH and reduce aggregation, thereby improving ROS (Reactive Oxygen Species)-mediated effect of photodynamic therapy (PDT) in cancer cells[1]. |
| Invitro | Having two maleimide axial substituents, Mal-Pc exhibits faster accumulation in cancer cells and then can react with GSH to deplete GSH and reduce aggregation, thereby improving ROS-mediated anticancer effect of PDT[1]. The fluorescence imaging demonstrated that Mal-Pc eliminate from normal cells faster due to the highly hydrophilic reaction product[1]. |
| Name | Mal-Pc |
| Formula | C46H28N10O8Si |
| Molar Mass | 876.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Juanjuan Chen, et al. Novel molecular photosensitizer with simultaneously GSH depletion, aggregation inhibition and accelerated elimination for improved and safe photodynamic therapy. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114938. |