| Bioactivity | Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL)[1]. |
| Invitro | Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) 可以促进主要内皮粘附分子及白细胞整合素受体的表达，从而增强白细胞的内皮粘附[1]。Macrophage-activating lipopeptide 2 (1 µg/mL, 2 h) 可以促进内皮 MyEnd 细胞中蛋白激酶 B 和 eNOS 的磷酸化，从而促进 NO 释放[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Macrophage-activating lipopeptide 2 TFA 相关抗体: |
| In Vivo | Macrophage-activating lipopeptide 2 (1 µg 溶于 125 µL PBS 中; 每天 1 次; 10 天; 静脉注射) 可以改善接受实验性股动脉结扎 (FAL) 的高胆固醇血症 Apoe 缺陷小鼠后肢的灌注恢复和侧支生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Sequence | {S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-Lys |
| Shortening | {S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-GNNDESNISFKEK |
| Formula | C99H167N19O30S.xC2HF3O2 |
| Molar Mass | 2135.56 (free base) |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Troidl K, et al. The Lipopeptide MALP-2 Promotes Collateral Growth. Cells. 2020 Apr 16;9(4):997. |
Macrophage-activating lipopeptide 2 TFA
CAS: F: C99H167N19O30S.xC2HF3O2 W: 2135.56 (free base)
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopept
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