Mabuterol hydrochloride_product_DataBase

Bioactivity	Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2].
Invitro	Mabuterol hydrochloride (10-60 µM; 48 h) 抑制 PDGF-BB 诱导的 ASMC 增殖[2]。Mabuterol hydrochloride (50 µM; 1h) 抑制 PDGF-BB (25ng/ml) 诱导的细胞内 Ca2+ 增加[2]。Mabuterol hydrochloride(50 µM; 48 h) 显着抑制 PDGF-BB 诱导的 Drp-1、cyclinD1 和 PCNA 蛋白表达，并增强 Mfn-2 表达[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Mabuterol hydrochloride 相关抗体: Cell Viability Assay[2] Cell Line:
CAS	54240-36-7
Formula	C13H19Cl2F3N2O
Molar Mass	347.20
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yamamoto I, et al. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6(3):261-76. [2]. Yaru Gu, et al. Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca2+]i and mitochondrial fission/fusion. Interactions, 2019, 307: 63-72.

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