| Bioactivity | MZ82, Ko 143 (HY-10010) derivative, is a ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor with the IC50 of ~23 nM. MZ82 not only shows greatly improved metabolic stability over Ko 143 (HY-10010) in liver microsomes but also in mice, and is able to penetrate into the brain[1]. |
| Formula | C26H29N3O3 |
| Molar Mass | 431.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yu Q, et al. Modulation of ABCG2 Transporter Activity by Ko143 Derivatives. ACS Chem Biol. 2024 Nov 15;19(11):2304-2313. |