MYX1715

CAS: 2445448-66-6 F: C25H29ClN6O2 W: 480.99

MYX1715 is an inhibitor for N-Myristoyltransferase (NMT) with KD of 0.09 nM. MYX1715 inhibits the proliferation of LU088

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Bioactivity	MYX1715 is an inhibitor for N-Myristoyltransferase (NMT) with KD of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin[1][2].
CAS	2445448-66-6
Formula	C25H29ClN6O2
Molar Mass	480.99
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhang J, et al. Dysregulation of MYC-Family Proteins Sensitises Cancers to NMT Inhibition: Identification of NMTi Sensitivity and Mechanism[J]. Cancer Research, 2023, 83(7_Supplement): 4871-4871. [2]. Carr R, et al. N-Myristoyltransferase (NMT) inhibitors are completely novel payloads for Antibody Drug Conjugates that deliver extensive tumor regression at well tolerated doses[J].