| Bioactivity | MYC-RIBOTAC is a ribonuclease-targeting chimera (RIBOTAC) to MYC internal ribosome entry site (IRES).MYC-RIBOTAC contains a MYC mRNA-binder and a small molecule that recruits and locally activates RNase L1 and decreases the mRNA and protein expression levels of MYC, induces apoptosis. MYC-RIBOTAC can be used for anticancer research[1]. |
| Invitro | MYC-RIBOTAC (0-10 μM；48 小时) 以剂量依赖和 RNase L 依赖的方式降低了 HeLa 细胞中 MYC mRNA 的丰度和蛋白水平[1]。MYC-RIBOTAC (0-10 μM；48 小时) 在 HeLa 细胞和 Namalwa 细胞中具有抗增殖和诱导凋亡作用[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | MYC-RIBOTAC |
| Formula | C55H58N10O11S |
| Molar Mass | 1067.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tong Y, et.al. Programming inactive RNA-binding small molecules into bioactive degraders. Nature. 2023 Jun;618(7963):169-179. |