| Bioactivity | MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1]. |
| Target | IC50: 12 nM (USP30)EC50: 32 nM (TOM20, the outer mitochondrial membrane protein) |
| Name | MTX115325 |
| CAS | 2750895-97-5 |
| Formula | C18H16N6O2 |
| Molar Mass | 348.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fang TZ et al. Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model. Nat Commun. 2023 Nov 13;14(1):7295. |
MTX115325
CAS: 2750895-97-5 F: C18H16N6O2 W: 348.36
MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity.
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