| Bioactivity | MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. MTH1 activator-1 can be used to probe the cellular and biological effects of upregulated oxidative damage repair in nucleotide pools and to delay or abrogate tumorigenesis[1]. |
| CAS | 2803422-60-6 |
| Formula | C29H23F3N4O2 |
| Molar Mass | 516.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee Y, et al. Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1. ACS Chem Biol. 2022 Aug 19;17(8):2074-2087. |
MTH1 activator-1
CAS: 2803422-60-6 F: C29H23F3N4O2 W: 516.51
MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels i
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