| Bioactivity | MT477 is a potent protein kinase C (PKC) inhibitor. MT477 induces apoptosis and necrosis. MT477 decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1. MT477 shows antitumor activity[1]. |
| Invitro | MT477 (0.05 mM; 1, 24 h) 以时间依赖性方式诱导细胞凋亡和坏死[1]。MT477 (0.05 mM; 0.5, 1, 2, 4 h) 以时间依赖性方式降低 Ras-GTP、p-Erk1/2、p-Elk1 的蛋白质表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MT477 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| In Vivo | MT477 (33, 100, 1000 µg/kg; i.p.; once a day on days 1, 4, 8, 16, 18, 20) 显示出抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 328069-91-6 |
| Formula | C31H30N2O12S3 |
| Molar Mass | 718.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jasinski P, et al. A novel quinoline, MT477: suppresses cell signaling through Ras molecular pathway, inhibits PKC activity, and demonstrates in vivo anti-tumor activity against human carcinoma cell lines. Invest New Drugs. 2008 Jun;26(3):223-32. |