| Bioactivity | MT-7 is a potent mitotic inhibitor. MT-7 shows antiproliferative activity. MT-7 induces cell cycle arrest at G2/M phase. MT-7 induces specific, reversible mitotic arrest and inhibits the polymerization of cellular microtubules[1]. |
| Invitro | MT-7 (0-8µM; 72 h) 抑制细胞增殖，对 HeLa、HL60、A549、MDA-MB-468、Lovo、HCT116、SMMC-7721、HO-8910、A375 和 SG7901 细胞的 IC50 值范围为 0.85 μM 至 5.01 μM[1]。MT-7 (5 μM; 12 h) 诱导细胞周期停滞在 G2/M 期[1]。MT-7 (5 μM; 1.5、3、6、12 h) 增加 THBS、IL6 和 PHLDA1 的基因表达，降低 COX5B、RPS11 和 CYP26A1 的基因表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MT-7 相关抗体: Cell Cycle Analysis[1] Cell Line: |
| CAS | 946507-08-0 |
| Formula | C22H17N3O2 |
| Molar Mass | 355.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang Z, et al. MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules. Invest New Drugs. 2010 Dec;28(6):715-28. |