| Bioactivity | MSN8C, an analog of mansonone E, is a novel catalytic inhibitor of human DNA topoisomerase II. MSN8C induces cancer cell apoptosis. MSN8C shows significant anti-tumor cell proliferation activity in vitro[1]. |
| Invitro | MSN8C 防止超螺旋 DNA 进入催化循环，以避免被 Topo II 毒物捕获并减少 DNA 碎片的产生[1]。MSN8C (1-10 μM, 24 h) 通过以剂量依赖性方式增加 caspase-3 表达来诱导凋亡[1]。MSN8C (1、5、10、20 μM，12 小时) 增加 HL-60 细胞中的 caspase-8 和 caspase-9 活性[1]。MSN8C (48 h) 可抑制 11 种不同来源的人类肿瘤细胞系，平均 IC50 值为 2.60 µM[1]。MSN8C 对人乳腺癌阿霉素耐药细胞系 MCF-7/Adr 和米托蒽醌耐药细胞系 HL-60/MX2 具有很强的抗增殖作用[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | MSN8C（10 mg/kg，腹腔注射，两天间隔，持续 2 周）在 A549 肿瘤异种移植模型中抑制肿瘤生长，且毒性更低[1]. Animal Model: |
| Name | MSN8C |
| CAS | 1314798-31-6 |
| Formula | C13H10O3 |
| Molar Mass | 214.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jie-Bin Ou, et al. MSN8C: A Promising Candidate for Antitumor Applications as a Novel Catalytic Inhibitor of Topoisomerase II. Molecules. 2023 Jul, 28(14). |