| Bioactivity | MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1]. |
| Invitro | MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner[1]. |
| Name | MSN-125 |
| CAS | 1592908-16-1 |
| Formula | C36H38BrN3O6 |
| Molar Mass | 688.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
MSN-125
CAS: 1592908-16-1 F: C36H38BrN3O6 W: 688.61
MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilizatio
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