MSC 2032964A_product_DataBase

Bioactivity	MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1(ASK1) with IC50 of 96 nM. MSC 2032964A preserves the visual responses in EAE mice model and exhibits potency in ameliorating the neuroinflammation[1].
Invitro	MSC 2032964A (10 μM) 显示出良好的代谢稳定性，微粒体清除率 0 --> MSC 2032964A 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	MSC 2032964A (5 mg/kg，口服) 在 SD 大鼠中的口服生物利用度为 82%，清除率为 1.1 L/kg/h，半衰期为 5.2 小时，分布容积 Vss 1.0 L/kg[1]。MSC 2032964A (30 mg/kg，口服，每天一次共 40 天) 可减轻脊髓和视神经病变产生的神经症状，从而改善 C57BL/6J 小鼠模型中由 MOG (35-55) (HY-P1240) 诱导的自身免疫性脑脊髓炎[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1124381-43-6
Formula	C16H13F3N6O
Molar Mass	362.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Guo X, et al., Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med. 2010 Dec;2(12):504-15.

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