| Bioactivity | MS7 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). NAMPT is the rate-limiting enzyme in the NAD+ biosynthetic pathway, responsible for converting nicotinamide to nicotinamide mononucleotide, which is then converted to NAD+. NAMPT is overexpressed in many cancer cells to meet the continuous replenishment of NAD+ required for rapid proliferation. PROTAC A7, a derivative of MS7, is an effective NAMPT degrader. MS7 can be used in cancer research[1]. |
| CAS | 1593654-46-6 |
| Formula | C24H27N5O2S2 |
| Molar Mass | 481.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu Y, et al. NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion[J]. Acta Pharmaceutica Sinica B, 2022, 12(6): 2859-2868. |