| Bioactivity | MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10-8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions[1]. |
| CAS | 541535-31-3 |
| Formula | C22H24N2O |
| Molar Mass | 332.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Latif R, et al. New small molecule agonists to the thyrotropin receptor. Thyroid. 2015 Jan;25(1):51-62. |