| Bioactivity | MS182 (compound 11) is an acetylation targeting chimera (AceTAC) designed based on p53Y220C stabilizer and targeting p53Y220C. MS182 is composed of p53Y220C and p300/CBP binders, respectively, coupled by a linker. MS182 forms a ternary complex with p300/CBP acetyltransferase and p53Y220C in a time- and concentration-dependent manner, effectively acetylating lysine at position 382 of p53Y220C (ACE50: 1.52 μM). MS182 also exhibited considerable bioavailability in mice, with GI50 values of 2.16 μM and 1.83 μM for BxPC3 (p53Y220C/-) and NUGC (p53Y220C/+), respectively[1]. |
| Target | ACE50: 1.52 μM (p53Y220C) |
| CAS | 3034773-62-8 |
| Formula | C57H68FN7O7S |
| Molar Mass | 1014.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs) |
MS182
CAS: 3034773-62-8 F: C57H68FN7O7S W: 1014.26
MS182 (compound 11) is an acetylation targeting chimera (AceTAC) designed based on p53Y220C stabilizer and targeting p53
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