| Bioactivity | MS154 is a first-in-class E3 ligase cereblon-recruiting EGFR degrader with Kds of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutants. MS154 potently inhibits cell proliferation in lung cancer cells[1]. |
| Name | MS154 |
| CAS | 2550393-21-8 |
| Formula | C46H54ClFN8O8 |
| Molar Mass | 901.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Meng Cheng, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63(3):1216-1232. |
MS154
CAS: 2550393-21-8 F: C46H54ClFN8O8 W: 901.42
MS154 is a first-in-class E3 ligase cereblon-recruiting EGFR degrader with Kds of 1.8 nM and 3.8 nM for EGFR WT and EGFR
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.