| Bioactivity | MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with IC50=5.92 nM for hP2Y14R and IC50=4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model[1]. |
| CAS | 2801627-78-9 |
| Formula | C30H24F3NO3 |
| Molar Mass | 503.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wen Z, et al. Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists[J]. Journal of Medicinal Chemistry, 2023, 66(13): 9076-9094. |
MRS4833
CAS: 2801627-78-9 F: C30H24F3NO3 W: 503.51
MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with IC50=5.92 nM for hP2Y14R and IC50=
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