| Bioactivity | MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment[1][2]. | |||||||||
| Name | MRS1334 | |||||||||
| CAS | 192053-05-7 | |||||||||
| Formula | C31H26N2O6 | |||||||||
| Molar Mass | 522.55 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. P G Baraldi, et al. New potent and selective human adenosine A(3) receptor antagonists. Trends Pharmacol Sci. 2000 Dec;21(12):456-9. [2]. Aya Galal, et al. Selective A3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity. Cancer Chemother Pharmacol. 2016 Feb;77(2):309-22. |