| Bioactivity | MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 µM[1]. | ||||||||||||
| Target | PDE4 | ||||||||||||
| Invitro | MR-L2 (0.3-10 μM; 1 h) significantly suppresses cAMP elevation and cysts formation in MDCK cells[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | MR-L2 | ||||||||||||
| CAS | 2374703-19-0 | ||||||||||||
| Formula | C19H16Cl3FN4O | ||||||||||||
| Molar Mass | 441.71 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Omar F, et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329. |
MR-L2
CAS: 2374703-19-0 F: C19H16Cl3FN4O W: 441.71
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates repr
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