| Bioactivity | MPO-IN-8 is an orally active myeloperoxidase (MPO) inhibitor. MPO-IN-8 can inhibit the generation of hypochlorous acid in neutrophils and the release of extracellular traps (NETosis). In mice with gouty arthritis, MPO-IN-8 can reduce swelling, lower peroxidase activity, and decrease IL-1β levels[1]. |
| CAS | 62578-87-4 |
| Formula | C12H9N3O2 |
| Molar Mass | 227.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Matos IA, et al. Targeting Myeloperoxidase Ameliorates Gouty Arthritis: A Virtual Screening Success Story. J Med Chem. 2024 Jul 25;67(14):12012-12032. |