| Bioactivity | MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1]. |
| Target | IC50: 0.22 μM (MPO peroxidation), 2.8 μM (hERG binding), 30 μM (TPO) |
| Name | MPO-IN-5 |
| CAS | 2476764-11-9 |
| Formula | C24H24N6O2 |
| Molar Mass | 428.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020 Jun 15;28(12):115548. |