MPH-220_product_DataBase

Bioactivity	MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].
Invitro	MPH-220 (0-50 µM) 抑制人肌肉肌球蛋白样品中肌动蛋白激活的 ATP 酶活性[1]。
In Vivo	MPH-220 (25-30 mg/kg，腹腔注射或口服灌胃) 可降低麻醉大鼠的骨骼肌力量，而不会影响心血管[1]。MPH-220 (15 mg/kg，口服) 改善脑损伤大鼠的步态功能[1]。 Animal Model:
Name	MPH-220
CAS	2649776-79-2
Formula	C20H21N3O3S
Molar Mass	383.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gyimesi M, et al. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. 2020 Oct 15;183(2):335-346.e13.

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