MNK1/2-IN-8_product_DataBase

Bioactivity	MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest[1].
Invitro	MNK1/2-IN-8 (compound 15b) 对 HCT-116、MOLM-13、K562 和 HL-60 的 GI50 值分别为 7.68、1.59、3.60 和 2.39 μM [1]。MNK1/2-IN-8 (compound 15b) (1、2和4μM, 24 h) 诱导 MOLM-13 和 K562 细胞系细胞发生周期阻滞[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MNK1/2-IN-8 相关抗体:
In Vivo	MNK1/2-IN-8 (compound 15b) 在小鼠肺癌 LL/2 细胞异种移植模型中抑制肿瘤生长[1] MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2430793-35-2
Formula	C26H24N6O
Molar Mass	436.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Xing K, Zhang H, Wang S, et al. Design, synthesis and biological evaluation of 4-(indolin-1-yl)-6-substituted-pyrido[3,2-d]pyrimidine derivatives as Mnk1/2 inhibitors. Eur J Med Chem. 2024;272:116499.

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