| Bioactivity | MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner[1]. |
| Invitro | MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC50s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively[1].MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | MNK1/2-IN-6 |
| Formula | C27H24N6O |
| Molar Mass | 448.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |