| Bioactivity | MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0.003 µM and 0.003 µM for MNK1 and MNK2 respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research[1]. |
| Invitro | MNK inhibitor 9 (Compound 9) 抑制 CaMK2D、FLT3、PIM2 和 ROCK2 的活性，IC50 分别为 0.69 µM、0.28 µM、0.73 µM 和 0.37 µM[1]。MNK inhibitor 9 抑制 KMS11-luc 人多发性骨髓瘤肿瘤细胞系的增值，EC50 值为 1.7 µM[1]。 |
| Name | MNK inhibitor 9 |
| CAS | 1889336-59-7 |
| Formula | C25H29N9O |
| Molar Mass | 471.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Han W, et al. Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design. J Med Chem. 2016 Apr 14;59(7):3034-45. |
MNK inhibitor 9
CAS: 1889336-59-7 F: C25H29N9O W: 471.56
MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0.003 µM and 0.003 µM for MNK1 and M
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