| Bioactivity | MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively[1]. | ||||||||||||
| Invitro | MMPI-1154 (1-100 μM) inhibits MMP-2 enzyme isolated from rat heart in vitro, and 100% inhibition appears at the concentraction 100 μM[1].MMPI-1154 (1 μM) shows significant cardio-cytoprotecion, significantly decreases infarct size in an ex vivo model for acute myocardial infarction[1]. | ||||||||||||
| Name | MMPI-1154 | ||||||||||||
| CAS | 1382722-47-5 | ||||||||||||
| Formula | C26H24FN3O3 | ||||||||||||
| Molar Mass | 445.49 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Péter Bencsik, et al. Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection.Front Pharmacol. 2018 Apr 5;9:296. |
MMPI-1154
CAS: 1382722-47-5 F: C26H24FN3O3 W: 445.49
MMPI-1154 is a promising novel cardio-cytoprotectiveimidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and ca
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