MMP-9-IN-5_product_DataBase

Bioactivity	MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers[1].
Invitro	MMP-9-IN-5 (compound 8, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].MMP-9-IN-5 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively[1].MMP-9-IN-5 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively [1].MMP-9-IN-5 (3.1 nM, 24 h) inhibits cell migration in HepG-2 cells[1]. Cell Viability Assay[1] Cell Line:
Name	MMP-9-IN-5
CAS	2581824-80-6
Formula	C27H20IN3O4
Molar Mass	577.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mohammed Salah Ayoup, et al. Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis. Eur J Med Chem. 2020 Jan 15;186:111875.

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