| Bioactivity | MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of 10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity[1][2][3][4]. |
| Invitro | MMK1 在人 FPRL1 转染的 HEK 293 (FPRL1/293) 细胞中诱导钙动员，EC50 为 2 nM[1]。 MMK1 (1μM; 4 小时) 诱导表达 FPR2 的 RBL-2H3 细胞的选择性迁移[3]。 |
| Name | MMK1 |
| CAS | 271246-66-3 |
| Sequence | Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met |
| Shortening | LESIFRSLLFRVM |
| Formula | C75H123N19O18S |
| Molar Mass | 1610.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
MMK1
CAS: 271246-66-3 F: C75H123N19O18S W: 1610.96
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of 10000 nM for FPR
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