| Bioactivity | MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A[1][2][3]. |
| Invitro | MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay[4]. |
| Name | MMAF hydrochloride |
| CAS | 1415246-68-2 |
| Formula | C39H66ClN5O8 |
| Molar Mass | 768.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |
MMAF hydrochloride
CAS: 1415246-68-2 F: C39H66ClN5O8 W: 768.42
MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agen
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