| Bioactivity | MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs). |
| Invitro | MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1]. |
| Name | MMAD |
| CAS | 203849-91-6 |
| Formula | C41H66N6O6S |
| Molar Mass | 771.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |