| Bioactivity | MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC50 of 2.2 μM. MM0299 inhibits cell proliferation of Mut6 with an IC50 of 0.0182 μM, through generation of 24(S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol[1]. |
| CAS | 474255-10-2 |
| Formula | C26H23NO5 |
| Molar Mass | 429.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nguyen TP, et al., Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18. |