| Bioactivity | MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia[1]. |
| Invitro | MM-401 maintains high binding affinity to WDR5 with a Ki value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM[1].MM-401 is able to specifically inhibit MLL1 activity (IC50 value of 0.32µM) by blocking MLL1-WDR5 interaction and thus the complex assembly[1].MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells[1].MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion[1].MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis[1]. Apoptosis Analysis[1] Cell Line: |
| Name | MM-401 TFA |
| CAS | 1442106-11-7 |
| Formula | C31H47F3N8O7 |
| Molar Mass | 700.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
MM-401 TFA
CAS: 1442106-11-7 F: C31H47F3N8O7 W: 700.75
MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor.MM-401 inhibits MLL1 activity (IC50 = 0.32 µM) by blocking MLL1
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