| Bioactivity | MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM[1]. |
| Target | IC50: 14 nM (MALT1) |
| Invitro | MLT-747 (0-20 μM) stabilizes cellular MALT1-W580S with an EC50 of 314 nM[1]. |
| Name | MLT-747 |
| CAS | 2097853-86-4 |
| Formula | C20H21Cl2N7O3 |
| Molar Mass | 478.33 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313. |
MLT-747
CAS: 2097853-86-4 F: C20H21Cl2N7O3 W: 478.33
MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.