| Bioactivity | ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo[1]. | ||||||||||||
| Name | ML372 | ||||||||||||
| CAS | 1331745-61-9 | ||||||||||||
| Formula | C18H20N2O4S | ||||||||||||
| Molar Mass | 360.43 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Mahlet B Abera, et al. ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice. JCI Insight. 2016 Nov 17;1(19):e88427. |
ML372
CAS: 1331745-61-9 F: C18H20N2O4S W: 360.43
ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRN
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.