PeptideDB

ML372

CAS: 1331745-61-9 F: C18H20N2O4S W: 360.43

ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRN
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Bioactivity ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo[1].
Name ML372
CAS 1331745-61-9
Formula C18H20N2O4S
Molar Mass 360.43
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reference [1]. Mahlet B Abera, et al. ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice. JCI Insight. 2016 Nov 17;1(19):e88427.