| Bioactivity | ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC50=0.24 μM). ML385 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics[1]. |
| Target | IC50: 0.24 μM (SKN-1) |
| Name | ML358 |
| CAS | 1158607-44-3 |
| Formula | C21H26Cl3NO2 |
| Molar Mass | 430.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peddibhotla, S, et al. Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes. ACS Chemical Biology, 10(8), 1871–1879. |