| Bioactivity | ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC90 and IC99 values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy[1]. |
| Target | IC90: 1 μM (non-replicating Mycobacterium tuberculosis bacilli)IC99: 4 μM (non-replicating Mycobacterium tuberculosis bacilli) |
| Invitro | ML338 (0-50 μM) has potency and selectivity against non-replicating M. tuberculosis with an IC90 of 1 μM. Additionally, ML338 have an IC99 against non-replicating M. tuberculosis (4 μM) which is excellent relative to current TB drugs[1].ML338 (0-50 μM; 48 hours) shows no toxicity to J774 macrophage cells up to 50 μM, the highest concentration[1].ML338 is against the non-replicating M. tuberculosis with IC90 and IC99 velues of 1 μM and 4 μM, respectively by CFU. Additionally, it against the replicating M. tuberculosis with IC90 and IC99 velues of 62 μM and 62 μM, respectively by CFU[1]. |
| Name | ML338 |
| CAS | 1630160-25-6 |
| Formula | C17H12ClN5OS |
| Molar Mass | 369.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Partha P. Nag,et al. Elucidation of the Physiology of Non-Replicating, Drug Tolerant Mycobacterium tuberculosis With the Aid of the Small Molecule Probe ML338. Review |