| Bioactivity | ML337 is a selective and brain-penetrant negative allosteric modulator of mGlu3, with an IC50 of 593 nM. ML337 possesses a favorable dystrophia myotonica protein kinase (DMPK) and ancillary pharmacology profile[1]. | |||||||||
| Invitro | ML337 has no activity at mGlu1, 2, 4, 5, 6, 7 and 8 at concentrations up to 30 μM[1]. | |||||||||
| Name | ML337 | |||||||||
| CAS | 1443118-44-2 | |||||||||
| Formula | C21H20FNO3 | |||||||||
| Molar Mass | 353.39 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Wenthur CJ, et, al. Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM). J Med Chem. 2013 Jun 27; 56(12): 5208-12. |