| Bioactivity | ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1]. | ||||||||||||
| Target | EC50: 0.7 μM (H1N1). | ||||||||||||
| Invitro | ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | ML303 | ||||||||||||
| CAS | 1638211-04-7 | ||||||||||||
| Formula | C21H16F3N3O2 | ||||||||||||
| Molar Mass | 399.37 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119. |