| Bioactivity | ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1]. | ||||||||||||
| Invitro | ML289 (VU0463597) is a CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) negative allosteric modulator probe[1]. | ||||||||||||
| Name | ML289 | ||||||||||||
| CAS | 1382481-79-9 | ||||||||||||
| Formula | C22H23NO3 | ||||||||||||
| Molar Mass | 349.42 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sheffler DJ, et al. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012;22(12):3921-3925. |